Marijuana legalization is a hot topic across the United States, with enactment of both recreational and medical marijuana laws taking place at a rapid pace. Consequently, employers face the daunting task of not only staying abreast of the quick-changing landscape of marijuana laws, but also determining how to handle the myriad of issues that marijuana legalization presents to their workforces—including compliance with the marijuana statutes themselves, underlying disability issues with medical marijuana, safety concerns, and the interplay between marijuana and drug testing. Combine these issues with the difficulty employers face in recruiting and retaining employees, and it amounts to an increasingly complex challenge. This article will address ten challenges employers may confront when dealing with marijuana legalization laws.